Converge 2026: Connecting the Autonomic dots

Understanding Your Body’s Interconnected Sensitive Systems

If you live with Postural Orthostatic Tachycardia Syndrome (POTS), hypermobile Ehlers-Danlos Syndrome (hEDS), or Mast Cell Activation Syndrome (MCAS), your daily experience with digestion can feel incredibly unpredictable. It is common to feel like your body is constantly throwing random curveballs at you. One of the most validating takeaways from the general medicine sessions at the Converge 2026 conference is that these symptoms are not in your head, nor are they a series of separate, disconnected faults. Instead, they represent a highly sensitive, deeply interconnected triad of systems that talk to each other constantly.

When we translate the science into a supportive framework, we see three distinct themes:

  • The Structural Picture (hEDS/HSD): Collagen is the foundational scaffolding of our entire digestive tract. When your body naturally produces a softer, more flexible type of collagen, the physical walls of the gut have less structural stiffness. This natural tissue laxity makes it physically harder for the body to move food along smoothly, which can show up as intense bloating, feeling full quickly, or changes in how your gut moves.

  • The Communication Link (POTS): The gut has its own intricate network of nerves, often called the "second brain," which balances blood flow and digestion. In a highly responsive autonomic nervous system, blood can pool in the abdomen, meaning your body has to work much harder to keep everything balanced, especially after eating.

  • The Protective Immune Response (MCAS): Mast cells are our body's brilliant front-line defenders. However, when they are hyper-reactive, they release chemical signals like histamine that create localised irritation, heighten your body’s internal sensitivity to pain, and alter how food is tolerated.

The Somatic Connection

From a somatic regulation perspective, we view the gut as a sensitive mirror of your nervous system's overall equilibrium. Because standard structural testing (like standard endoscopies or routine scans) often looks for obvious physical damage, your results might come back completely normal, even when you are experiencing profound discomfort. This does not mean your symptoms are not real; it simply means the tests are looking at the structure rather than the function.

When your gut is working beautifully with a highly sensitive nervous system, practicing gentle, non-judgmental tracking can help you learn your body's personal language. Rather than fighting the symptom, we can use somatic tools - like calming down a post-meal adrenaline rush with slow, extended exhales - to signal safety to both the brain and the belly.

Where to Find More Information:

To explore this interconnected triad further, look into the following resources:

To really deep dive into this topic, we have collated the following peer reviewed articles:

  • The Structural & Autonomic Overlap: Aziz Q, Harris LA, Goodman BP, Simrén M, Shin A. (2025). AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review.Clinical Gastroenterology and Hepatology, 23(8), 1291-1302.

  • The Gut-Brain Spectrum: Lam et al. (2022). Greater Overlap of Rome IV Disorders of Gut-Brain Interactions Leads to Increased Disease Severity and Poorer Quality of Life.Clinical Gastroenterology and Hepatology, 20(5), e945-e956.

  • The Global MCAS Consensus: Afrin LB, Weinstock LB, et al. (2021). Diagnosis of mast cell activation syndrome: a global “consensus-2”.Diagnosis, 8(2), 137-152. (See also the 2026 follow-up: Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years, accessible via PubMed).

Navigating Your Health Journey

Managing a highly sensitive system requires a specialised, validating approach that looks at your physiology from the inside out. If you are looking for practical guidance, community tools, or clinical partnership:

  • Explore our curated POTS Resource Hub for evidence-based guides, pacing toolkits, and supportive structural strategies.

  • If you are ready to explore how somatic regulation and bottom-up therapies can support your unique symptom profile, you can book an initial consultation to begin mapping out your personalised care plan.

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Converge 2026: Bridging the Autonomic Gap